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药学院导师简介——陈兰美教授
2018-08-29 16:09  

陈兰美,1982年2月,汉族,中共党员,药物化学教授,硕士生导师,广东医科大学海洋与热带医学学院海洋化学教研室主任。澳大利亚Murdoch University,分子医学与创新治疗中心访问学者。广东省自然科学基金评审专家及Journal of Medicinal Chemistry, Chemical Engineering Journal, Advanced Science, Theranostics, European Journal of Medicinal Chemistry等杂志审稿人。先后主持国家自然科学青年基金,广东省自然科学基金,广东省优秀青年教师培养项目,广东省卫生厅及中药局等课题。以第一或通讯作者在国际知名SCI期刊上发表高水平论文38篇,H-index: 31,其中近五年来发表18篇。申请国家发明专利11项,已授权9项。(联合)培养硕士研究生18名。讲授《基础化学》、《有机化学》、《药物化学》及相应实验课程。

研究方向:靶向型海洋天然产物-金属配合物的设计、合成及其抗肿瘤/抗菌机制研究。

联系方式:lanmeichen@126.com

代表性项目:

(1) 2025年广东省自然科学基金面上项目(主持),近红外光响应NO可控释放的靶向型钌配合物的构建及其抗菌机制研究,(No. 2025A1515010381,2025.01-2027.12)

(2) 2024年广东医科大学东莞创新研究院纳米技术及应用工程研究中心开放课题重点项目(主持),基于适配体的生物传感器用于阿维菌素的可视化检测, (2024.5-2026.5)

(3) 2021年湛江市科技计划项目(主持):精准靶向非小细胞肺癌环金属铱诊疗一体试剂的开发, (No. 2021A05044,2021.10-2023.10.)

(4) 2017年度国家自然科学基金项目(青年基金)(主持):Cyclo-Ru-IQ的设计、合成及其抑制Nrf2逆转非小细胞肺癌顺铂耐药的分子机制,(No. 21701034, 2018.01-2020.12.)

(5) 2016年度广东省中医药局科研课题(主持):纳米硒增敏木犀草素诱导肺癌细胞凋亡的机制研究(No: 20161143, 2016.4-2018.1.)

代表性论文专利:

[1] Xufeng Zhu1, Jinjun Chen1, Binhua Wu, Yating Huang, Yan Zou, Chunmei Liang, Yingnian Lu*, Hui Luo, Lanmei Chen*, Jincan Chen*, Polyvalent copper oxide nanozymes: Co-delivery of ROS and NO for inducing cuproptosis-like bacterial death against MRSA infections, Chemical Engineering Journal, 2024, 499, 156507.

[2] Jincan Chen1, Qian Wu1, Shenting Zhang, Jie Gao, Wenzhu Yu, Tianling Hu, Jiale Zhu, Miao Guo, Xufeng Zhu*, Lanmei Chen*, The efficient screening of avermectin B1a aptamer and colorimetric detection of its regulation of RuNPs activity, Microchemical Journal, 2024, 206, 111429.

[3] Xufeng Zhu1, Chunmei Liang1, Jinjun Chen, Jie Gao, Weigang Chen, Qianqian Ouyang, Lianxiang Luo, Zunnan Huang, Hui Luo, Lanmei Chen*, Jincan Chen*, Phase separation of extracellular polymeric substances induced by bacteria responsive Nano-Antibiotics for drug-resistant bacterial infection management, Chemical Engineering Journal, 2024, 481, 148136.

[4] Lanmei Chen, Hong Tang, Tianling Hu, Jie Wang, Qianqian Ouyang, Xufeng Zhu*,Rui Wang, Wenyong Huang, Zunnan Huang*, Jincan Chen*, Three Ru(II) complexes modulate the antioxidant transcription factor Nrf2 to overcome cisplatin resistance, Journal of Inorganic Biochemistry, 2024, 259, 112666.

[5] Xufeng Zhu#, Qiang Sun#, Xinhua Guo, Chunmei Liang, Yao Zhang, Wenyong Huang, Wenliang Pei, Zunnan Huang*, Lanmei Chen*, Jincan Chen*, Cyclometalated ruthenium (II) complexes induced HeLa cell apoptosis through intracellular reductive injury, Journal of Inorganic Biochemistry, 2023, 112333.

[6] Weigang Chen, Xianhong Cai, Qiang Sun, Xinhua Guo, Chunmei Liang, Hong Tang,3 Heming Huang, Hui Luo, Lanmei Chen*, Jincan Chen*, Design and synthesis of aptamer-cyclometalated iridium(III) complex conjugate targeting cancer cells, European Journal of Medicinal Chemistry, 2022, 236, 114335.

[7] Lanmei Chen, Jie Wang, Xianhong Cai, Suxiang Chen, Jingjing Zhang, Baojun Li, Weigang Chen, Xinhua Guo, Hui Luo*, Jincan Chen*, Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway, Bioorganic Chemistry, 2022, 119, 105516.

[8] Jincan Chen, Yuanyuan Deng, Jie Wang, Suxiang Chen, Fa Peng, Xuerong He, Meijun Liu, Hui Luo*, Jingjing Zhang*, Lanmei Chen*, Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling, Journal of Biological Inorganic Chemistry, 2021, 26, 793–808.

[9] Tao Wang#, Lanmei Chen#, Arpitha Chikkanna, Suxiang Chen, Isabell Brusius, Nabayet Sbuh, Rakesh N. Veedu*, Development of nucleic acid aptamer-based lateral flow assays: A robust platform for cost-effective point-of-care diagnosis, Theranostics, 2021, 11, 5174-5196

[10] 陈兰美,陈锦灿,吴谦,朱旭峰,张沈婷,郭淼,一种阿维菌素B1a适配体及其筛选方法和应用,中国,发明专利,专利号:ZL 2024 1 0158148.1,申请日:2024.02.04,授权日:2025.01.24。

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