一、学习和工作经历

1997.09-2001.07 安徽科技学院（现安徽科技工程大学），工学学士

2004.09-2007.07 南京农业大学，工学硕士

2007.09-2010.07 华南理工大学，工学博士

2010.07-2023.04 广东海洋大学，讲师、副教授、教授

2023.05-至今 广东医科大学，教授

2013.12-2017.12 华南理工大学-无限极（中国）有限公司，博士后

2019.04-2020.04 新加坡国立大学，国家公派访问学者

二、研究领域

主要围绕水产食品质量保真与海洋活性物质高值化利用开展应用基础研究，具体包括以下三个方向：

1. 食源蛋白肽抗衰老机制解析与高效制备：主要聚焦线粒体等细胞器蛋白质代谢动力学失衡，探究酒精性认知损伤、皮肤光老化，以及饮食失衡相关代谢性疾病发生发展的细胞和分子基础，识别早期生化级联途径和特定分子靶点，进而从海洋资源中研发具有显著干预效应的食源性蛋白肽生物制品。

2. 海洋食品品质劣变生物学机制与绿色控制：主要聚焦肌肉细胞蛋白骨架降解级联规律与调控靶点识别，探究对虾、生蚝等湛江大宗特色海洋食品冷链流通期间品质劣变的生物学机制，进而研发靶向控制技术和开发绿色保鲜保活添加剂。

3. 海洋微生物与酶资源挖掘及生物制剂研发：围绕海洋食品保鲜和功能肽等活性物质的开发需求，设计特定筛选体系，从海洋生物资源中挖掘特定功能微生物及酶，并研究其发酵制备和高效表达系统，进而研发面向海洋食品质量保真和功能食品制备的特定微生物和酶制剂。

三、主要学术成果

1. 科研项目

[1] 主持“十三五”国家重点研发计划项目“水产品陆海联动保鲜保活与冷链物流技术（2019YFD0901600）”课题1“水产品陆海联动远距离保活流通与品质监控关键技术及装备研发（2019YFD0901601）”中子课题“活体水产品陆海联动保活流通全程品质监测与评估技术研究”，70万，2019.12~2022.12；

[2] 主持国家自然科学基金项目“无水保活流通过程中南美白对虾冰温损伤的靶点识别与应答机制（31772048）”，60万，2017.01~2021.12；

[3] 主持国家自然科学基金项目“丝氨酸蛋白酶介导的酚氧化酶原激活诱发冷藏对虾黑变规律与机制（31201309）”，25万，2013.01~2015.12；

[4] 主持中国博士后科学基金项目“基于突触可塑与ERK通路解析食源肽改善酒精性脑损伤（2014M552203）”，5万，2014.08~2016.12；

[5] 主持广东省自然科学基金项目“冷藏对虾肌原纤维响应钙蛋白酶系统的磷酸化调控级联规律与驱动机制（2023A1515010852）”10万，2023.01~2014.12；

[6] 主持广东省科技厅项目“海洋低温葡萄糖氧化酶高产菌株的筛选与应用（2013B021100016）”，30万，2014.08~2017.09；

[7] 主持中央高校基本业务费项目“基于胞外基质代谢调控网络解析食源性弹性蛋白肽EP-1抗皱机制(20152M062)”，9万，2014.01~2015.12；

[8] 主持湛江市社会民生科技项目“新型海洋芽孢杆菌Bacillus sp. CAMT 22370高产葡萄糖氧化酶的菌株选育与生物保鲜剂创制”，5万，2026.01~2017.12；

[9] 主持广东省教育厅生物医药与健康（食品）重点领域项目“HPA轴介导鳕鱼蛋白肽TCH缓解酒精性认知损伤的作用途径与分子机制（2024ZDZX2072）”，4万，2024.10~2027.10；

[10] 主持广东省教育厅项目“海洋低温葡萄糖氧化酶高产菌株的筛选与应用（2014KTSCX078）”，6万，2013.08~2016.12；

2. 学术著作

徐德峰 著. 食源肽改善皮肤光老化的途径与机制（中国博士后优秀学术专著），科学出版社，2021,7.

3. 授权专利

[1] 国家发明专利:徐德峰, 叶日英, 孙力军, 王雅玲,伍彬, 廖建萌. 一种改良型水产品生物保鲜剂、其制备方法及用途; 专利号: ZL201510468118.1.

[2] 国家发明专利: 徐德峰, 李彩虹, 叶日英, 孙力军, 王雅玲, 廖建萌. 一种芽孢杆菌Bacillus sp. CAMT22370及其应用; 专利号: ZL 201510468214.6.

[3] 国家发明专利: 徐德峰, 李彩虹, 孙力军, 王雅玲, 叶日英, 江侧燕. 一种蛹虫草多糖组合物、其生产方法及用途, 专利号: ZL201310486770.7.

[4] 国家发明专利: 赵谋明, 徐德峰, 崔春, 赵海锋. 米曲霉HG76及其应用, 专利号: ZL201010276159.

[5] 实用新型专利：徐德峰，马忠华，赵谋明，苏国万，张婷，胡远忠. 一种大鼠皮肤光老化动物模型装置, 专利号: ZL201520152906.5.

4. 部分代表性论文

[1] Li Caihong, He Jiaxin, Wu Ruiqi, Cai Luyun, Weng Wuyin, Zhao Mouming, Xu Defeng*. Novel antiphotoaging peptides from bovine Ligamentum nuchae proteins hydrolysates: Based on Sprague-dawley rat model and molecular docking. Journal of Agricultural and Food Chemistry, 2025, 73, 26190-26205.

[2] Xu Defeng, Linchun Mao, Shanggui Deng, Jing Xie, Hui Luo. TMT-proteomics provides a sight into the underlying mechanism of flesh quality degradation of Litopenaeus vannamei during refrigerated waterless transport at 12 ^oC. Journal of Agricultural and Food Chemistry, 2023, 71, 50, 20304-20313.

[3] Xu Defeng, Zhao Mouming. Theragra chalcogramma hydrolysates, rich of fragment Gly-Leu-Pro-Ser-Tyr-Thr, ameliorate alcohol-induced cognitive impairment via attenuating neuroinflammation and enhancing neuronal plasticity in Sprague-Dawley rats. Journal of Agricultural and Food Chemistry, 2022, 70(39): 12513-12524.

[4] Xu Defeng, Zhao Mouming. Walnut protein hydrolysates ameliorate alcohol-induced cognitive impairment (AICI) by alleviating oxidative stress and inflammation in brain and improving hippocampal synaptic plasticity in Sprague-Dawley rats. Food & Function, 2022, 13, 11615 - 11626.

[5] Xu Defeng, Li Caihong, Zhao Mouming. Attenuation of UV-induced skin photoaging in rats by walnut protein hydrolysates is linked to modulation of MAPK/AP-1 and TGF-β/Smad signaling pathways. Food & Function，2022, 13, 609-623.

[6] Xu Defeng, Wang Weiqiong, Liao Jianmeng, Liao Lan, Li Caihong, Zhao Mouming. Walnut proteins hydrolysates, rich with peptide fragments of WSREEQEREE and ADIYTEEAGR, ameliorate UV-induced photoaging through inhibition of NF-κB/MMP-1 signaling pathway in female rats. Food & Function，2020, 11, 10601-10616.

[7] Xu Defeng, Zhao Mouming. Photoaging induced by long-term exposure to UV irradiation and amelioration by Skipjack tuna skin hydrolysates: Targeting inhibition of MAPK and NF-κB signaling hyperactivation. Journal of Functional Foods, 2022, 98, 10251.

[8] Zhu S., Hu L., He J., Feng J., Li C*, Xu D*. First microstructure insights into the dynamic degradation of structural proteins components of shrimp Litopenaeus vannamei during refrigeration and its association with texture deterioration: Based on histochemical staining and biochemical analysis. Journal of Food Composition and Analysis, 2025, 148, 108270.

[9] Xu Defeng, Lin Haisheng, Zhao Mouming Li Caihong. Theragra chalcogramma hydrolysates, rich of Gly-Leu-Pro-Ser-Tyr-Thr, exerts anti-photoaging potential via targeting MAPK and NF-κB pathways in SD rats. Marine Drugs, 2022, 20(5), 286-300.

[10] Xu Defeng, Li Caihong, Zhao Mouming. Theragra chalcogramma hydrolysate, rich in Gly-Leu-Pro-Ser-Tyr-Thr, alleviates photoaging via modulating deposition of collagen fibers and restoration of extracellular components matrix in SD Rats. Marine Drugs, 2022, 20(4), 252-266.

[11] Xu Defeng, Li Dan, Zhao Zijian, Wu Jiaxin, Zhao Mouming. Regulation of walnut protein hydrolysate on the components and structural degradation of photoaged skin in SD rats. Food & Function, 2019, 10: 6792-6802.

[12] Zheng Xiaoxian, Xu Defeng*, Sun Lijun, Qin Xiaoming, Zhang Ying. Inflammation and apoptosis pathways mediated the stress response of Litopenaeus vannamei to acute cold and air exposure during waterless live transportation: Based on ultrastructure and transcriptome. Fish and Shellfish Immunology, 2022, 131: 391-400.

[13] Xu Defeng, Sun Lijun, Qin Xiaoming. Waterless live transport degrades the flesh quality of Litopenaeus vannamei by disturbing neuroendocrine response: based on physiology and metabolomics[J]. Journal of the Science of Food and Agriculture, 2022, 103(8): 3882-3895.

[14] Xu Defeng, Xue Hongmei, Sun Lijun, Wang Yaling. Retardation of melanosis development and quality degradation of Litopenaeus vannamei with starving treatment during cold storage. Food control, 2018, 92: 412-419.

[15] Xu Defeng, Wang Yaling, Sun Lijun, Liu Huanming, Li Jianrong. Inhibitory activity of a novel antibacterial peptide AMPNT-6 from Bacillus subtilis aganist Vibrio parahaemolyticus in shrimp. Food Control, 2013, 30(1): 58-61.

[16] Xu Defeng, Sun Lijun, Li Caihong, Wang Yaling, Ye Riying. Inhibitory effect of glucose oxidase from Bacillus sp. CAMT22370 on the quality deterioration of Pacific white shrimp during cold storage. LWT-Food Science and Technology, 2018, 92: 339-346.

[17] Xu Defeng, Yang Xianqing, Wang Yaling, Sun Lijun. Cascading mechanism triggering the activation of polyphenol oxidase zymogen in shrimp Litopenaeus vannamei after postmortem and the correlation with melanosis development[J]. Food and Bioprocess Technology, 2020, 13(7): 1131-1145.

[18] Xu Defeng, Pan Li, Zhao Haifeng, Zhao Mouming, Sun Jiaxin, Liu Dongmei. Breeding and identification of novel koji molds with high activity of acid protease by genome recombination between Aspergillus oryzae and Aspergillus niger. Journal of Industrial Microbiology and Biotechnology, 2011, 38(9):1255-1265.

[19] Xu Defeng, Wu Jiaxin, Sun Lijun, Qin Xiaoming, Fan Xiuping, Zheng Xiaoxian. Combined stress of acute cold exposure and waterless duration at low temperature induces mortality of shrimp Litopenaeus vannamei through injuring antioxidative and immunological response in hepatopancreas tissue. Journal of Thermal Biology, 2021, 100, 103080.

[20] Xu Defeng, Zheng Xiaoxian, Li Caihong, Wu Jiaxin, Sun Lijun, Qin Xiaoming, Fan Xiuping. Insights into the response mechanism of Litopenaeus vannamei exposed to cold stress during live transport combining untargeted metabolomics and biochemical assays. Journal of Thermal Biology, 2022, 104, 103200.

[21] Xu Defeng, Wu Jiaxin, Sun Lijun, Qin Xiaoming, Fan Xiuping, Zheng Xiaoxian. Energy metabolism response of Litopenaeus vannamei to combined stress of acute cold exposure and waterless duration: Implications for physiological regulation and waterless live transport. Journal of Thermal Biology, 2022, 104, 103149.

[22] Xu Defeng, Wu Jiaxin, Sun Lijun, Qin Xiaoming, Fan Xiuping, Zheng Xiaoxian. Antioxidative and immunological response of shrimp Litopenaeus vannamei to combined stress of acute cold exposure and waterless duration: Implications for live transport. Aquaculture Research, 2022, 53(3): 1026-1039.

[23] Xu Defeng, Li Caihong, Wang Yaling, Sun Lijun_, Zhao Haifeng_, Zhao Mouming. Characterization of acid proteases from a fusant F76 and its progenitors Aspergillus oryzae HN3042 and Aspergillus niger CICC2377. International Journal of Food Science and Technology, 2013, 48(4): 678-684.

[24] Li Caihong, Xu Defeng*, Zhao Mouming, Sun Lijun, Wang Yaling. Production optimization, purification, and characterization of a novel acid protease from a fusant by Aspergillus oryzae and Aspergillus niger. European Food Research Technology, 2014, 238(6): 905-917.

[25] 蔡沛峰, 廖威龙, 冯骏, 胡利, 李彩虹, 徐德峰*. 南美白对虾肌肉骨架蛋白特异性染色及其冷藏期间参与质构劣化的作用[J]. 食品科学, 2025, 46(4): 252-259.

[26] 徐德峰, 马忠华, 赵谋明, 张婷, 苏国万. 四种食源肽对光老化皮肤氧化与炎症系统的影响[J]. 华南理工大学学报（自然科学版）, 2018, 46(6): 87-92.

5. 科技奖励

[1] 徐德峰，谢晶，邓尚贵，李彩虹，蔡路昀，廖建萌，王雅玲，陈升，冼上华. 冷藏对虾质量安全控制关键技术创新与应用. 2024年广东省科技进步二等奖.

[2] 徐德峰，谢晶，邓尚贵，李彩虹，王雅玲，冼上华，吕刚，陈升. 冷藏对虾质量安全控制关键技术创新与应用. 2024年自然资源部科技进步二等奖.

[3] 徐德峰, 李彩虹, 孙力军, 廖建萌, 陈康健, 邓旗. 冷藏对虾品质劣变关键途径ProPO-AS的识别及其靶向控制技术研发与应用. 2023年中国轻工业联合会科技进步二等奖.

[4] 徐德峰, 李彩虹, 廖建萌, 孙力军, 王雅玲, 陈康健, 陈丹，邓旗，房志家，刘健，邱伟蓝，李志鹏，高平. 冷藏对虾品质劣变关键控制技术与应用. 2022年中国商业联合会科技进步一等奖.

[5] 徐德峰, 陈康健, 廖建萌, 叶日英, 孙力军, 王雅玲, 杨曦, 徐彬彬. 冷藏对虾黑变酶学机制与控制技术研究及应用，2018年中国海洋学会海洋科技进步二等奖.

[6] 徐德峰, 廖建萌, 杨曦, 李彩虹, 陈康健, 叶日英, 孙力军, 王雅玲, 徐彬彬. 南美白对虾内源酶活性调控技术与保鲜应用，2018年广东省农业技术推广奖二等奖.

[7] 徐德峰, 李彩虹, 廖建萌, 杨曦, 叶日英, 孙力军, 王雅玲, 陈康健, 伍彬, 徐彬彬. 南美白对虾内源酶活性调控技术与保鲜应用，2019年中国商业联合会科技进步三等奖.

四、招生主要方向

食源活性成分高效挖掘与健康应用；水产食品保鲜与高质加工

五、联系方式

通讯地址：广东省湛江市霞山区文明东路2号 广东医科大学海洋与热带医学学院

邮箱：13827198525@163.com