庄满娇,女,汉族,1989年2月生,理学博士,副教授,硕士生导师,广东医科大学药学院药理教研室教师。2019年毕业于四川大学华西药学院,获药理专业博士学位;2020年3月入职广东医科大学药学院药理教研室。主要从事糖尿病,肿瘤相关分子药理学,及相关药物载体研究。近5年来,发表SCI论文7篇,含第两篇1区SCI论文,5篇2区论文;获批校级课题3项,市厅级项目1项,省级课题2项,国家级课题1项;
近5年基金项目
(1) 广东医科大学博士启动基金项目, 4SG20205P, hucMSC 外泌体协同双功能促胰岛素分泌剂改
善胰岛β 细胞的功效与机制研究, 2020-07 至 2022-06, 15万元;
(2) 2022年广东医科大学“百项青年研究项目资助计划”项目基金,基于核酸适配体的长效靶向胰岛载体设计及对T2DM的疗效机制研究,2022-011至2023-11,2万元;
(3)广东省基础与应用基础研究基金区域联合基金-青年基金项目, 2020A1515110862,基于外泌体多肽缓释载药系统设计及其治疗二型糖尿病研究, 2020-10 至 2023-09, 10万元;
(4) 广东省基础与应用基础研究基金区域联合基金-地区培育项目, 2021B1515140060,eccDNA在乳腺癌紫杉醇耐药中的表达机制及靶向治疗策略, 2021-10 至 2024-09, 30万元;
(5) 国家自然科学基金青年科学基金项目, 82204435, Tubulin-β III eccDNA启动子重构在微管蛋白介导乳腺癌紫杉醇耐药中关键作用的机制研究, 2023-01-01 至 2025-12-31, 30万元;
近5年相关代表论文
(1) Manjiao Zhuang; Honghong Qiu; Ping Li; Lihua Hu; Yayu Wang; Lei Rao; Islet protection and amelioration of type 2 diabetes mellitus by treatment with quercetin from the flowers of Edgeworthia gardneri, Drug Design, Development and Therapy, 2018, 12: 955-966
(2) Manjiao Zhuang; Dan Du; Lingling Pu; Haixing Song; Mian Deng; Qian Long; Xiaofei Yin; Yayu Wang; Lei Rao; SPION‐Decorated Exosome Delivered BAY55‐9837 Targeting the Pancreas through Magnetism to Improve the Blood GLC Response, Small, 2019, 15(12): e1903135
(3) Manjiao Zhuang; Xuelian Chen; Dan Du; Jiamei Shi; Mian Deng; Qian Long; Xiaofei Yin; Yayu Wang; Lei Rao; SPION decorated exosome delivery of TNF-α to cancer cell membranes through magnetism, Nanoscale, 2020, 12(4): 173-188
(4) Manjiao Zhuang; Lei Rao; Yadi Chen; Shangying Xiao; Haishan Xia; Jiangyong Yang; Xiaohua Lv; Dongyun Qin; Chunjie Zhu ; Controlled SPION-Exosomes Loaded with Quercetin Preserves Pancreatic Beta Cell Survival and Function in Type 2 Diabetes Mellitus, International Journal of Nanomedicine, 2023, 18: 5733-5748
(5) Yan, Lin; Chen, Yadi; Zhang, Shihao; Zhu, Chunjie; Xiao, Shangying; Xia, Haishan; Chen, Xiaohua; Guo, Dan; Lv, Xiaohua; Rao, Lei; Zhuang, Manjiao ; Reconstruction of TNF-α with specific isoelectric point released from SPIONs basing on variable charge to enhance pH-sensitive controlled-release, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2024, 60
