胡显镜，医学博士，博士后合作导师、硕士生导师，东莞市特色人才，广东医科大学高层次人才。国家中药现代化工程技术研究中心东莞分中心副主任、东莞市中医药防治消化道疑难病证重点实验室、东莞市毒性中药临床应用与基础研究重点实验室、东莞市慢性炎症防治重点实验室副主任。博士毕业于暨南大学，香港浸会大学博士后。主持国家级、省市级项目12项。在Cancer Letter; Cell Death Dis; Int J Biol Macromol; J Ethnopharmacol等期刊发表SCI论文40篇；授权9项专利。
研究方向：
（1）肿瘤与炎症药理；
（2）肠道微生态紊乱与肝肠疾病；
（3）中医药大健康产品研发
主持的部分研究项目：
[1] 国家外国专家个人类项目(H类)，工程化益生菌靶向调节肿瘤内胆固醇代谢抗肠癌作用研究;
[2] 2025年度省部共建中亚高发病成因与防治国家重点实验室联合基金重点项目，肠道菌Ocillibacter valericigenes调节胆固醇代谢抗2型糖尿病作用及机制研究，SKL-HIDCA-2025-GD1B;
[3] 国家外国专家个人类项目(Y类)，基于“钩钓策略”的掌叶酒瓶树抗肝癌药效物质基础及靶标发现研究，Y20240168;
[4] 广东省自然科学基金面上项目，2023A1515011116，基于与肠道菌群双向调控机制探讨中药活性分子Ardisiacrispin B治疗溃疡性结肠炎及其调控机体Th17/Treg免疫平衡作用;
[5] 广东省中医药局项目面上项目，20241159，冬虫夏草基于调控肠-肺交互机制改善小鼠肺纤维化作用研究;
[6] 东莞市社会发展科技项目重点项目，20231800939832；基于改善肝肠循环研究中医经方黄连平胃散治疗溃疡性结肠炎合并肝损伤作用及其分子机制;
[7] 湛江市科技发展专项基金竞争分配性项目，2022A01003，基于调控“肝-肠循环”研究琴叶榕防治原发性肝癌作用及其制剂开发;
[8] 国家自然科学基金青年基金，81503303，海洋中药毛蚶新多肽H3在乏氧微环境下抗肝癌作用及其机制研究；
[9] 广东省自然科学基金，博士启动基金，2015A030310226，海洋中药毛蚶新多肽H3抗肝癌及靶向PI3K/AKT/mTOR作用机制研究；
[10] 广东省自然科学基金，自由探索项目，2016A030313825，基于乏氧微环境下研究毛蚶新多肽H3抗肝癌及其作用机理。
近五年部分代表作：
[1] Hidayat Ullah &, Huanli Cui &, Yu Li , Binghuang Ye, Weijie Peng , Yongdui Ruan , Weibo Dai * , Chunling Ma* , Xianjing Hu*. Natural triterpenoid Ardisiacrispin B attenuates colitis-associated cancer via JAK2/STAT3 pathway and gut microbiota modulation. Natural Products and Bioprospecting, 2026 Mar 11;16(1):45.
[2] Yongdui Ruan†，Yitong Chen†，Weijie Peng†，Yuting Duan†，Qing Luo，Hidayat Ullah，Muhammad Majid，Hoi Leong Xavier Wong，Yanfeng Xie*， Weibo Dai*，Xianjing Hu*. Ardisiacrispin B, a natural triterpenoid saponins, suppresses dextran sulfate sodium-induced inflammatory bowel disease by rebalancing the gut microbiota and Th17/Treg of mice. 2025 Nov 19. Inflammopharmacology, 2025, 34(1): 597-617
[3] Muhammad Majid†, Bing Tang, Yingyao Lai†, Xiaoyan Pang† ,Yongdui Ruan, Hui Shi,Weiwen Peng, Weibo Dai*, Xianjing Hu*. Ficus pandurata as a functional phytotherapeutic: inhibiting JAK2/STAT3 signaling and activating mitochondrial apoptosis in hepatocellular carcinoma. Food Science & Nutrition, 2025; 13: e71114.
[4] Hidayat Ullah, Yamina Alioui, Xiaoye Liu, Sharafat Ali, Bing Tang, Hongmei Lu, Yongdui Ruan*and Xianjing Hu*. Deglet Noor date derived polysaccharides lower blood glucose levels and modulate the gut microbiota in a streptozotocin-induced type-1 diabetic mouse model. Food & Function, 2025, 16, 4477 - 4492.
[5] Ximin Wang 1, Qing Luo 1, Jing Yang 1, Weijie Peng, Gengting Dong *, Xianjing Hu **, Weibo Dai *. Clinacanthus nutans restores the intestinal barrier in UC via regulatings oxidative stress to suppress the occurrence of ferroptosis. Journal of Functional Foods, 2025, 129: 106863.
[6] Liu Cao, Mengyuan Niu, Xiaoqing Tang, Yiting Wang, Xianjing Hu*& Weibo Dai*. Gentiopicroside improves DSS-induced ulcerative colitis and secondary liver injury in mice by enhancing the intestinal barrier and regulating the gut microbiome. Sci Rep. 2025 Jul 25;15(1):27159. doi: 10.1038/s41598-025-12255-5.
[7]Weihong Kuang†, Jialin Xu†, Fenting Xu, Weizhen Huang, Muhammad Majid, Hui Shi, Xia Yuan*, Yongdui Ruan* and Xianjing Hu*. Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review. Frontiers in Cell and Developmental Biology. 2024, 12.
[8] Huang Qiang#, Peng Weijie#, Luo Qing#, Zhao Wenchang, Dai Weibo*, Zeng Huifen*, Wong Hoi Leong Xavier, Hu Xianjing*. Exploring the mechanism of Suxin Hugan Fang in treating ulcerative colitis based on network pharmacology. Sci Rep. 2024 Nov 8;14(1):27196.
[9] Xiaokang Wang# , Xianjing Hu#, Chunxiao Ye, Jingqian Zhao, Shing Cheng Tan , Liangbin Zhou, Chenyu Zhao, Kit Hang Wu, Xixiao Yang, Jinbin Wei* and Maoxun Yang*. Astragalus polysaccharide enhances voriconazole metabolism under inflammatory conditions through the gut microbiota. J Clin Transl Hepatol. 2024 May 28;12(5):481-495.
[10] Zhang S, Xing N, Jiao Y, Li J, Wang T, Zhang Q, Hu X, Li C, Kuang W. An arabinan from Citrus grandis fruits alleviates ischemia/reperfusion-induced myocardial cell apoptosis via the Nrf2/Keap1 and IRE1/GRP78 signaling pathways. Carbohydr Polym. 2025 Jan 1;347:122728.
[11] Weibo Dai#, Jing Yang#, Xin Liu#, Quanxi Mei*, Weijie Peng, Xianjing Hu*. Anti-colorectal cancer of Ardisia gigantifolia Stapf. and targets prediction via network pharmacology and molecular docking study. BMC Complementary Medicine and Therapies, 2023, 23(1): 4.
[12] Weibo Dai#, Xiaoyan Pang#, Weiwen Peng#, Xinyi Zhan, Chang Chen, Wenchang Zhao, Congyan Zeng, Quanxi Mei, Qilei Chen, Weihong Kuang*, Zhanping Gou and Xianjing Hu*. Liver protection of a low-polarity fraction from Ficus pandurata Hance, prepared by supercritical CO2 fluid extraction, on CCl4-induced acute liver injury of mice via inhibiting apoptosis and ferroptosis mediated by strengthening anti-oxidation. Molecules, 2023, 28, 2078.
[13] Xinyi Zhan#, Weijie Peng#, Zhuqiang Wang#, Xin Liu, Weibo Dai*, Quanxi Mei*, Xianjing Hu*. Polysaccharides from garlic protect against liver injury in DSS-induced inflammatory bowel disease of mice via suppressing pyroptosis and oxidative damage. Oxidative Medicine and Cellular Longevity, 2022, 2022: 2042163.
[14] Weibo Dai#, Chang Chen#, Gengting Dong#, Guangru Li, Weiwen Peng, Xin Liu, Jing Yang, Leyu Li*, Ruiyan Xu, Xianjing Hu*. Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation. Journal of Ethnopharmacology, 2022, 294: 115338.
[15] Xianjing Hu#, Sarwat Fatima#, Minting Chen,Tao Huang, Yuen Wa Chen, Ruihong Gong, Hoi Leong Xavier Wong, Rongmin Yu, Liyan Song, Hiu Yee Kwan*, Zhaoxiang Bian*. Dihydroartemisinin is potential therapeutics for treating late-stage CRC by targeting the elevated c-Myc level. Cell Death and Disease, 2021, 12: 1053.
[16] Xianjing Hu#, Sarwat Fatima#, Minting Chen#, Keyang Xu, Chunhua Huang, Rui-Hong Gong, Tao Su, Hoi Leong Xavier Wong, Zhaoxiang Bian* and Hiu Yee Kwan*. Toll-like receptor 4 is a master regulator for colorectal cancer growth under high-fat diet by programming cancer metabolism. Cell Death and Disease, 2021, 12(8): 791.
[17] Weibo Dai#, Xinyi Zhan#, Weijie Peng#, Xin Liu, Weiwen Peng*, Quanxi Mei, Xianjing Hu*. Ficus pandurata Hance inhibits ulcerative colitis and colitis-associated secondary liver damage of mice by enhancing anti-oxidation activity. Oxidative Medicine and Cellular Longevity, 2021, 2021: 2617881.
[18] Weibo Dai#, Chang Chen#, Huiting Feng#, Guangru Li, Weiwen Peng*, Xin Liu, Jing Yang, Xianjing Hu*. Protection of Ficus pandurata Hance against acute alcohol-induced liver damage in mice via suppressing oxidative stress, inflammation, and apoptosis. Journal of Ethnopharmacology, 2021, 275: 114140.
[19] Weibo Dai#, Jing Yang#, Haili Cao#, Zhuqiang Wang, Guangru Li, Xiwen Zhong,Weiwen Peng, Chang Chen, Xin Liu, Congyan Zeng* and Xianjing Hu*. Clinical evidence-guided anti-rheumatoid arthritis study of Shuji tablet in adjuvant-induced arthritis rats and mechanism exploration via network pharmacological approach. Frontiers in Pharmacology, 2021 Jul 29;12: 694507.
[20] Yao Wen#, Sixue Bi#, Xianjing Hu#, Jianing Yang, Chunlei Li, Hang Li, Dong Bo Yu, Jianhua Zhu*, Liyan Song*, and Rongmin Yu*. Structural characterization and immunomodulatory mechanisms of two novel glucans from Morchella importuna fruiting bodies. International Journal of Biological Macromolecules, 2021, 183: 145-157.
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